Accelerators for Medicine
Particle accelerators play a significant role in the field of medicine, particularly in the areas of cancer treatment and medical imaging. Accelerators produce high-energy beams of particles, such as electrons, protons and heavy ions, which are used in radiation therapy to target and destroy cancer cells with high precision.
Additionally, accelerators assist in producing medical isotopes essential for various diagnostic and therapeutic procedures.
Medical Applications:
Positron Emission Tomography (PET)
Accelerators produce radioisotopes for PET scans, which create detailed images of metabolic activity in the body. This is crucial for detecting and monitoring conditions like cancer, neurological disorders, and heart disease.
Single Photon Emission Computed Tomography (SPECT)
In SPECT imaging, accelerators generate isotopes that allow doctors to view blood flow and organ function, aiding in the diagnosis of cardiovascular diseases, bone disorders, and infections.
Radiation Therapy
Linear accelerators (LINACs) generate high-energy x-rays or electrons that target and kill cancer cells while minimizing damage to surrounding healthy tissue.
Medical Isotope Production
Accelerators are used to produce short-lived isotopes like Technetium-99m, which is essential for a wide range of diagnostic imaging procedures. These isotopes are critical for non-invasive imaging techniques that help diagnose and monitor various medical conditions.
Proton Therapy
Proton accelerators provide a form of radiation therapy that uses protons rather than x-rays. This method delivers a precise dose of radiation to the tumour while sparing surrounding healthy tissues, making it particularly effective for treating certain types of cancer.
Boron Neutron Capture Therapy (BNCT)
BNCT is an advanced radiation treatment that targets cancer cells selectively. Proton accelerators are used to produce neutron beams by striking Lithium or Beryllium targets. When boron-10 is introduced into cancer cells, the neutron beam interacts with the boron, leading to localized cell destruction while sparing surrounding healthy tissue.
Equipment Sterilization
Accelerators are used in the sterilization of medical equipment by emitting high-energy electrons or x-rays to eliminate bacteria, viruses, and other pathogens. This method is efficient, reliable, and leaves no chemical residue.
Stable Isotope Production
Accelerators produce medical stable isotopes, which are essential for various diagnostic and therapeutic procedures, particularly in nuclear medicine.
X-ray Machines
X-ray machines in medical and dental settings utilize accelerators to generate X-rays by accelerating electrons to energies between 70 keV and 200 keV.
Cyclotron-Produced Radionuclides
Cyclotrons are used to produce many of the medical radioisotopes mentioned herein. These radionuclides are used for both imaging and treatment in nuclear medicine.
Electron Beam Therapy
Low-energy electron beams (~100 keV) generated by accelerators are used directly to treat skin cancer, offering a focused treatment option without converting the electrons to X-rays.
Books
Particle Accelerators in Medicine – Ervin B. Podgoršak
Advances in Accelerators and Medical Physics – Toshiyuki Shirai, Teiji Nishio and Kiyokazu Sato
Articles
A Review of Proton Therapy – Current Status and Future Directions – R. Mohan
Positron emission tomography – A. Berger
Recent Advances in SPECT Imaging – M. Madsen
Use of cyclotrons in medicine – S. Quaim
Medical applications of synchrotron radiation – P. Suortti
Applications of Particle Accelerators in Medical Physics – G. Cuttone
New Applications For Accelerators In Pharmaceutical Processes – D. Morisseau
Electron-beam accelerator with conversion to X-rays: Optimal radiation type according to application – A. Šagátová
Emerging technologies for cancer therapy using accelerated particles – C. Graeff
Electron Therapy for Skin Cancer and Dermatology – IntraOp
Cyclotron Produced Radionuclides: Principles and Practice – IAEA
Presentations
Medical Applications of Accelerators at CERN
Introduction to Clinical Linear Accelerators, Oncology Medical Physics
Podcasts/Videos
Precision medicine: meet two medical physicists who are making it possible
TedEd: Why do hospitals have particle accelerators?
Brian Egle – Stable Isotope Enrichment (youtube.com)
X Ray Machine | Part 2 | Biomedical Engineers TV
Additional Resources
Treatment Techniques: Linear Accelerators
IAEA: Nuclear Technology and Health Applications
Symmetry Magazine: How particle physics can save your life
Researchers develop electron beam accelerator to sterilize medical equipment, Phys.org